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Several members are mutated in different neuromuscular diseases including centronuclear myopathies and Charcot-Marie-Tooth CMT neuropathies, or are linked to a predisposition to obesity and cancer. While some members have phosphatase activity against the 3-phosphate of phosphoinositides, regulating the phosphorylation status of PtdIns3P and PtdIns 3,5 P2 implicated in membrane trafficking and autophagy, and producing PtdIns5P, others lack key residues in the catalytic site and are classified as dead-phosphatases.
However, these dead phosphatases regulate phosphoinositide-dependent cellular pathways by binding to catalytically active myotubularins. Here we review previous studies on the molecular regulation and physiological roles of myotubularins.
Wanted Dead or Alive
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Bon Jovi - Wanted Dead Or Alive
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Allen and features footage from the band's massive world tour, including shots from Buffalo NY' s Director: Wayne Isham. MTV Top Videos of the s. MTV Top Videos of All i Have Watched. Use the HTML below.
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- WANTED - Dead or alive: Myotubularins, a large disease-associated protein family.!
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